Publications

Broggini L, Bonnet DMV, Swiderska KW, Bender S, Codo GR, Lampis A, Martinez-Rivas G, Duchatelet P, Danigo A, Chaves-Sanjuan A, Sirac C, Ricagno S. Untwisted amyloid fibrils from a transgenic mouse model of AL amyloidosis. Amyloid. 2025 Dec 21:1-4. doi: 10.1080/13506129.2025.2605332.

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Tiberi M, Lapi M, Gourlay LJ, Chaves-Sanjuan A, Polentarutti M, Demitri N, Cavinato M, Bonnet DMV, Taglietti V, Righetti A, Sala R, Cauteruccio S, Kumawat A, Russo R, Barbiroli AG, Gnesutta N, Camilloni C, Bolognesi M, Messina G, Nardini M. Structural basis of Nuclear Factor 1-X DNA recognition provides prototypic insight into the NFI family. Nat Commun. 2025 Nov 19;16(1):10170. doi: 10.1038/s41467-025-65186-0.

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Bonnet DMVJ, Chaves-Sanjuan A, Contaldo N, De Stradis A, Caliandro R, Minafra A, Geuna F. Structural characterization of plum pox virus by cryo-electron microscopy. Arch Virol. 2025 Dec 1;171(1):11. doi: 10.1007/s00705-025-06473-5.

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Broggini L, Piccoli M, Chaves-Sanjuan A, Bonnet DMV, Cirillo F, Visentin C, Sonzini F, Signorelli P, Lavota I, Milazzo M, Nonnis S, Menicanti L, Ciconte G, Pappone C, Anastasia L, Ricagno S. Structural characterization of atrial natriuretic peptide amyloid fibrils from patients with atrial fibrillation. Nat Commun. 2025 Oct 29;16(1):9556. doi: 10.1038/s41467-025-64618-1.

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Genta M, Ferrara G, Capelli R, Rondelli D, Sertic S, Bolognesi M, Rizzi M, Rossi F, Jeruzalmi D, Chaves-Sanjuan A, Miggiano R. Mechanistic understanding of UvrA damage detection and lesion hand-off to UvrB in Nucleotide Excision Repair. Nat Commun. 2025 Apr 10;16(1):3416. doi: 10.1038/s41467-025-58670-0.

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Capaldi S, Guardini Z, Montepietra D, Pagliuca VF, Amelii A, Betti E, John C, Pedraza-González L, Cupellini L, Mennucci B, Bonnet DMV, Chaves-Sanjuan A, Dall’Osto L, Bassi R. Structural determinants for red-shifted absorption in higher-plants Photosystem I. New Phytol. 2025 Dec;248(5):2331-2346. doi: 10.1111/nph.70562.

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Chiarugi S, Margheriti F, De Lorenzi V, Martino E, Margheritis EG, Moscardini A, Marotta R, Chaves-Sanjuan A, Del Seppia C, Federighi G, Lapi D, Bandiera T, Rapposelli S, Scuri R, Bolognesi M, Garau G. NAPE-PLD is target of thiazide diuretics. Cell Chem Biol. 2025 Feb 20:S2451-9456(25)00031-5. doi: 10.1016/j.chembiol.2025.01.008.

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Puri S, Gadda A, Polsinelli I, Barzago MM, Toto A, Sriramoju MK, Visentin C, Broggini L, Valérie Bonnet DM, Russo R, Chaves-Sanjuan A, Merlini G, Nuvolone M, Palladini G, Gianni S, Hsu SD, Diomede L, Ricagno S. The Critical Role of the Variable Domain in Driving Proteotoxicity and Aggregation in Full-length Light Chains. J Mol Biol. 2025 Jan 20;437(5):168958. doi: 10.1016/j.jmb.2025.168958.

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Chaves-Sanjuan A, D’Abrosca G, Russo V, van Erp B, Del Cont-Bernard A, Capelli R, Pirone L, Slapakova M, Sgambati D, Fattorusso R, Isernia C, Russo L, Barton IS, Roop RM 2nd, Pedone EM, Bolognesi M, Dame RT, Pedone PV, Nardini M, Malgieri G, Baglivo I. Circular oligomeric particles formed by Ros/MucR family members mediate DNA organization in α-proteobacteria. Nucleic Acids Res. 2024 Dec 11;52(22):13945-13963. doi: 10.1093/nar/gkae1104. Erratum in: Nucleic Acids Res. 2025 Jan 7;53(1):gkae1269. doi: 10.1093/nar/gkae1269.

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Schulte T, Chaves-Sanjuan A, Speranzini V, Sicking K, Milazzo M, Mazzini G, Rognoni P, Caminito S, Milani P, Marabelli C, Corbelli A, Diomede L, Fiordaliso F, Anastasia L, Pappone C, Merlini G, Bolognesi M, Nuvolone M, Fernández-Busnadiego R, Palladini G, Ricagno S. Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis. Nat Commun. 2024 Jul 28;15(1):6359. doi: 10.1038/s41467-024-50686-2.

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Spizzichino S, Di Fonzo F, Marabelli C, Tramonti A, Chaves-Sanjuan A, Parroni A, Boumis G, Liberati FR, Paone A, Montemiglio LC, Ardini M, Jakobi AJ, Bharadwaj A, Swuec P, Tartaglia GG, Paiardini A, Contestabile R, Mai A, Rotili D, Fiorentino F, Macone A, Giorgi A, Tria G, Rinaldo S, Bolognesi M, Giardina G, Cutruzzolà F. Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1. Mol Cell. 2024 Jul 25;84(14):2682-2697.e6. doi: 10.1016/j.molcel.2024.06.016.

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Saponaro A, Krumbach JH, Chaves-Sanjuan A, Sharifzadeh AS, Porro A, Castelli R, Hamacher K, Bolognesi M, DiFrancesco D, Clarke OB, Thiel G, Moroni A. Structural determinants of ivabradine block of the open pore of HCN4. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2402259121. doi: 10.1073/pnas.2402259121.

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Puri S, Schulte T, Chaves-Sanjuan A, Mazzini G, Caminito S, Pappone C, Anastasia L, Milani P, Merlini G, Bolognesi M, Nuvolone M, Palladini G, Ricagno S. The Cryo-EM STRUCTURE of Renal Amyloid Fibril Suggests Structurally Homogeneous Multiorgan Aggregation in AL Amyloidosis. J Mol Biol. 2023 Sep 15;435(18):168215. doi: 10.1016/j.jmb.2023.168215.

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Freda I, Exertier C, Barile A, Chaves-Sanjuan A, Vega MV, Isupov MN, Harmer NJ, Gugole E, Swuec P, Bolognesi M, Scipioni A, Savino C, Di Salvo ML, Contestabile R, Vallone B, Tramonti A, Montemiglio LC. Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR. Nucleic Acids Res. 2023 Aug 25;51(15):8237-8254. doi: 10.1093/nar/gkad552.

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Milazzo FM, Chaves-Sanjuan A, Minenkova O, Santapaola D, Anastasi AM, Battistuzzi G, Chiapparino C, Rosi A, Merlo Pich E, Albertoni C, Marra E, Luberto L, Viollet C, Spagnoli LG, Riccio A, Rossi A, Santoro MG, Ballabio F, Paissoni C, Camilloni C, Bolognesi M, De Santis R. Spike mutation resilient scFv76 antibody counteracts SARS-CoV-2 lung damage upon aerosol delivery. Mol Ther. 2023 Feb 1;31(2):362-373. doi: 10.1016/j.ymthe.2022.09.010.

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Garcia-Pardo J, Bartolomé-Nafría A, Chaves-Sanjuan A, Gil-Garcia M, Visentin C, Bolognesi M, Ricagno S, Ventura S. Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3. Nat Commun. 2023 Jan 16;14(1):239. doi: 10.1038/s41467-023-35854-0.

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