Publications
Recent Publications
Mechanistic understanding of UvrA damage detection and lesion hand-off to UvrB in Nucleotide Excision Repair
Genta M, Ferrara G, Capelli R, Rondelli D, Sertic S, Bolognesi M, Rizzi M, Rossi F, Jeruzalmi D, Chaves-Sanjuan A, Miggiano R
Nature Communications
NAPE-PLD is target of thiazide diuretics
Chiarugi S, Margheriti F, De Lorenzi V, Martino E, Margheritis EG, Moscardini A, Marotta R, Chaves-Sanjuan A, Del Seppia C, Federighi G, Lapi D, Bandiera T, Rapposelli S, Scuri R, Bolognesi M, Garau G
Cell Chemical Biology
The Critical Role of the Variable Domain in Driving Proteotoxicity and Aggregation in Full-length Light Chain
Puri S, Gadda A, Polsinelli I, Barzago MM, Toto A, Sriramoju MK, Visentin C, Broggini L, Valérie Bonnet DM, Russo R, Chaves-Sanjuan A, Merlini G, Nuvolone M, Palladini G, Gianni S, Hsu SD, Diomede L, Ricagno S
Journal of Molecular Biology
2025
Michele Tiberi, Michela Lapi, Louise Jane Gourlay, Antonio Chaves-Sanjuan, Maurizio Polentarutti, Nicola Demitri, Miriam Cavinato, Diane Marie Valérie Jeanne Bonnet, Valentina Taglietti, Anna Righetti, Rachele Sala, Silvia Cauteruccio, Amit Kumawat, Rosaria Russo, Alberto Giuseppe Barbiroli, Nerina Gnesutta, Carlo Camilloni, Martino Bolognesi, Graziella Messina, Marco Nardini. Structural bases for Nuclear Factor 1-X activation and DNA recognition. Prototypic insight into the NFI transcription factor family. bioRxiv 2025.03.21.644642; doi: https://doi.org/10.1101/2025.03.21.644642
Chiarugi S, Margheriti F, De Lorenzi V, Martino E, Margheritis EG, Moscardini A, Marotta R, Chaves-Sanjuan A, Del Seppia C, Federighi G, Lapi D, Bandiera T, Rapposelli S, Scuri R, Bolognesi M, Garau G. NAPE-PLD is target of thiazide diuretics. Cell Chem Biol. 2025 Feb 20:S2451-9456(25)00031-5. doi: 10.1016/j.chembiol.2025.01.008.
Puri S, Gadda A, Polsinelli I, Barzago MM, Toto A, Sriramoju MK, Visentin C, Broggini L, Valérie Bonnet DM, Russo R, Chaves-Sanjuan A, Merlini G, Nuvolone M, Palladini G, Gianni S, Hsu SD, Diomede L, Ricagno S. The Critical Role of the Variable Domain in Driving Proteotoxicity and Aggregation in Full-length Light Chains. J Mol Biol. 2025 Jan 20;437(5):168958. doi: 10.1016/j.jmb.2025.168958.
2024
Chaves-Sanjuan A, D’Abrosca G, Russo V, van Erp B, Del Cont-Bernard A, Capelli R, Pirone L, Slapakova M, Sgambati D, Fattorusso R, Isernia C, Russo L, Barton IS, Roop RM 2nd, Pedone EM, Bolognesi M, Dame RT, Pedone PV, Nardini M, Malgieri G, Baglivo I. Circular oligomeric particles formed by Ros/MucR family members mediate DNA organization in α-proteobacteria. Nucleic Acids Res. 2024 Dec 11;52(22):13945-13963. doi: 10.1093/nar/gkae1104. Erratum in: Nucleic Acids Res. 2025 Jan 7;53(1):gkae1269. doi: 10.1093/nar/gkae1269.
Schulte T, Chaves-Sanjuan A, Speranzini V, Sicking K, Milazzo M, Mazzini G, Rognoni P, Caminito S, Milani P, Marabelli C, Corbelli A, Diomede L, Fiordaliso F, Anastasia L, Pappone C, Merlini G, Bolognesi M, Nuvolone M, Fernández-Busnadiego R, Palladini G, Ricagno S. Helical superstructures between amyloid and collagen in cardiac fibrils from a patient with AL amyloidosis. Nat Commun. 2024 Jul 28;15(1):6359. doi: 10.1038/s41467-024-50686-2.
Spizzichino S, Di Fonzo F, Marabelli C, Tramonti A, Chaves-Sanjuan A, Parroni A, Boumis G, Liberati FR, Paone A, Montemiglio LC, Ardini M, Jakobi AJ, Bharadwaj A, Swuec P, Tartaglia GG, Paiardini A, Contestabile R, Mai A, Rotili D, Fiorentino F, Macone A, Giorgi A, Tria G, Rinaldo S, Bolognesi M, Giardina G, Cutruzzolà F. Structure-based mechanism of riboregulation of the metabolic enzyme SHMT1. Mol Cell. 2024 Jul 25;84(14):2682-2697.e6. doi: 10.1016/j.molcel.2024.06.016.
Saponaro A, Krumbach JH, Chaves-Sanjuan A, Sharifzadeh AS, Porro A, Castelli R, Hamacher K, Bolognesi M, DiFrancesco D, Clarke OB, Thiel G, Moroni A. Structural determinants of ivabradine block of the open pore of HCN4. Proc Natl Acad Sci U S A. 2024 Jul 2;121(27):e2402259121. doi: 10.1073/pnas.2402259121.
2023
Puri S, Schulte T, Chaves-Sanjuan A, Mazzini G, Caminito S, Pappone C, Anastasia L, Milani P, Merlini G, Bolognesi M, Nuvolone M, Palladini G, Ricagno S. The Cryo-EM STRUCTURE of Renal Amyloid Fibril Suggests Structurally Homogeneous Multiorgan Aggregation in AL Amyloidosis. J Mol Biol. 2023 Sep 15;435(18):168215. doi: 10.1016/j.jmb.2023.168215.
Freda I, Exertier C, Barile A, Chaves-Sanjuan A, Vega MV, Isupov MN, Harmer NJ, Gugole E, Swuec P, Bolognesi M, Scipioni A, Savino C, Di Salvo ML, Contestabile R, Vallone B, Tramonti A, Montemiglio LC. Structural insights into the DNA recognition mechanism by the bacterial transcription factor PdxR. Nucleic Acids Res. 2023 Aug 25;51(15):8237-8254. doi: 10.1093/nar/gkad552.
Milazzo FM, Chaves-Sanjuan A, Minenkova O, Santapaola D, Anastasi AM, Battistuzzi G, Chiapparino C, Rosi A, Merlo Pich E, Albertoni C, Marra E, Luberto L, Viollet C, Spagnoli LG, Riccio A, Rossi A, Santoro MG, Ballabio F, Paissoni C, Camilloni C, Bolognesi M, De Santis R. Spike mutation resilient scFv76 antibody counteracts SARS-CoV-2 lung damage upon aerosol delivery. Mol Ther. 2023 Feb 1;31(2):362-373. doi: 10.1016/j.ymthe.2022.09.010.
Garcia-Pardo J, Bartolomé-Nafría A, Chaves-Sanjuan A, Gil-Garcia M, Visentin C, Bolognesi M, Ricagno S, Ventura S. Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3. Nat Commun. 2023 Jan 16;14(1):239. doi: 10.1038/s41467-023-35854-0.